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A Gold(I)‐Catalyzed Tandem Cyclization to Benzo[ b ]indeno[1,2‐ e ][1,4]diazepines from o ‐Phenylenediamines and Ynones
Author(s) -
Xie Fukai,
Zhang Bo,
Chen Yanyu,
Jia Hongwei,
Sun Lei,
Zhuang Kaitong,
Yin Lili,
Cheng Maosheng,
Lin Bin,
Liu Yongxiang
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000755
Subject(s) - chemistry , tandem , diazepine , catalysis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , ring (chemistry) , materials science , composite material
A gold‐catalyzed tandem cyclization of o ‐phenylenediamines with ynones to synthesize benzo[ b ]indeno[1,2‐ e ][1,4]diazepine has been developed. The mechanism was explored by control experiments. The method provides a way to access a range of benzo[ b ]indeno[1,2‐ e ][1,4]diazepine derivatives in diversity‐oriented synthesis aiming at discovering structurally diverse scaffolds.