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Rhodium‐Catalysed Reductive Amination for the Synthesis of Tertiary Amines
Author(s) -
Bianga Jonas,
Kopplin Niklas,
Hülsmann Jonas,
Vogt Dieter,
Seidensticker Thomas
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000746
Subject(s) - reductive amination , chemistry , rhodium , aldehyde , amine gas treating , selectivity , amination , catalysis , tertiary amine , organic chemistry , alcohol , combinatorial chemistry
A procedure for the synthesis of tertiary amines via reductive amination of aldehydes with molecular hydrogen as a reducing agent using homogeneous rhodium catalysis is presented. Using an amine to aldehyde ratio of 4/1 enabled the synthesis of tertiary amines from nine different aldehydes and nine different secondary amines with selectivities up to 99% and turnover frequencies (TOF) up to 7200 h −1 . The reaction showed a high tolerance against alcohol and ester functions allowing the formation of multifunctional molecules. In addition, secondary amines can also be produced by this synthesis. For all compounds, activities were determined by hydrogen gas‐uptake. In order to increase the sustainability and efficiency of the procedure, a dosing strategy has been successfully developed. Using the determined reaction indicators enabled the stoichiometric use of aldehydes and amines without significant loss of selectivity.