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Umpolung Strategy for α,α’‐Functionalization of Ketones with 2‐Aminothiophenols: Stereoselective Access to Spirobis(1,4‐benzothiazines)
Author(s) -
Nguyen Thanh Binh,
Retailleau Pascal
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000725
Subject(s) - chemistry , umpolung , stereoselectivity , surface modification , benzothiazine , catalysis , combinatorial chemistry , organic chemistry , medicinal chemistry , nucleophile
In the presence of TFA as a strong acid catalyst in DMSO, α,α’‐enolizable ketones were found to be stereoselectively α,α’‐functionalized with 2‐aminothiophenols to provide spirobis(1,4‐benzothiazine) derivatives.