Premium
Iron‐Promoted Domino Dehydrogenative Annulation of Deoxybenzoins and Alkynes Leading to β‐Aryl‐α‐Naphthols
Author(s) -
Zhu XueQing,
Guo RuiLi,
Zhang XingLong,
Gao YaRu,
Jia Qiong,
Wang YongQiang
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000625
Subject(s) - annulation , chemistry , domino , aryl , regioselectivity , substrate (aquarium) , combinatorial chemistry , scope (computer science) , organic chemistry , catalysis , alkyl , oceanography , computer science , programming language , geology
A strategy for synthesis of β‐aryl‐α‐naphthols has been established through an iron‐promoted domino C( sp 3 )−H/C( sp )−H and C( sp 2 )−H/C( sp )−H dehydrogenative coupling of deoxybenzoins and alkynes. The synthesis uses inexpensive materials with a broad substrate scope and features simple operations with excellent regioselectivity. This study provides an alternative access to various β‐aryl‐α‐naphthols and the synthetic protocol should have potential applications in medicinal, materials science, and related areas.