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Rhodium(III)‐Catalyzed C−H Benzylation of Indole's C3 Position with Aza‐ o ‐Quinone Methides
Author(s) -
Liu Ruixing,
Wei Yin,
Shi Min
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000613
Subject(s) - chemistry , indole test , rhodium , reagent , catalysis , deuterium , surface modification , combinatorial chemistry , quinone , medicinal chemistry , stereochemistry , organic chemistry , physics , quantum mechanics
In this paper, we report an example of indole's site selective C3 benzylation process through a rhodium(III)‐catalyzed indole's C2 activation relay using aza‐ o ‐QM as a functionalization reagent, affording the desired products in good yields under mild conditions. The plausible reaction mechanism is proposed on the basis of control and deuterium labeling experiments and the further transformation has been also described.