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Preparation of Oxindoles via Visible‐Light‐Induced Amination/Cyclization of Arylacrylamides with Alkyl Amines
Author(s) -
Wang YuZhao,
Lin WuJie,
Zou JianYu,
Yu Wei,
Liu XueYuan
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000609
Subject(s) - chemistry , amination , alkyl , radical , reductive amination , photoredox catalysis , cleavage (geology) , visible spectrum , catalysis , cascade , photochemistry , combinatorial chemistry , organic chemistry , photocatalysis , physics , geotechnical engineering , optoelectronics , chromatography , fracture (geology) , engineering
Abstract The cascade amination/cyclization of N ‐arylacrylamides with alkyl amines under visible‐light photoredox catalysis is realized via intermediacy of aminium radicals. The aminium radicals are generated by a two‐step sequence which involves N‐chlorination of alkyl amines and subsequent reductive N−Cl cleavage. This method provides a convenient access to aminated oxindoles.