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Synthesis of Azulenopyridinones through Palladium‐Catalyzed Oxidative [4+2] Cyclization Reactions of N ‐Methoxyazulene‐1‐ and 2‐carboxamides with Alkynes
Author(s) -
Han Gi Uk,
Son JeongYu,
Park Dahee,
Eom Hyeonsik,
Lee Kyungsup,
Noh Hee Chan,
Lee Kooyeon,
Lee Phil Ho
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000587
Subject(s) - chemistry , azulene , palladium , catalysis , oxidative phosphorylation , substrate (aquarium) , functional group , combinatorial chemistry , oxygen , medicinal chemistry , photochemistry , organic chemistry , biochemistry , oceanography , polymer , geology
Palladium‐catalyzed oxidative [4+2] cyclization reactions were developed from the C−H activation reaction of N ‐methoxyazulene‐1‐ and 2‐carboxamides with symmetrical and unsymmetrical alkynes under a molecular oxygen atmosphere, producing azulenopyridinone derivatives with novel azulene skeletons in good to excellent yields with a wide substrate scope and excellent functional group tolerance.
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