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N ‐Heterocyclic Carbene‐Catalyzed Enantioselective Intramolecular Annulations to Construct Benzo‐Fused Pyranones with Quaternary Stereocenter
Author(s) -
Dzieszkowski Krzysztof,
Rafiński Zbigniew
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000550
Subject(s) - stereocenter , enantioselective synthesis , chemistry , annulation , intramolecular force , carbene , michael reaction , stereochemistry , stereoselectivity , catalysis , organocatalysis , combinatorial chemistry , organic chemistry
A highly enantioselective intramolecular NHC‐catalyzed approach for the synthesis of benzo‐fused pyranones bearing quaternary stereocenter is described. The developed methodology is based on annulation reaction between acyl anion intermediates and β,β‐disubstituted Michael acceptors. The reaction offers streamlined and effective access to target products in a highly stereoselective manner.