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Palladium‐Catalyzed Regioselective Domino Spirocyclization of Carbamoyl Chlorides with Alkynes and Benzynes
Author(s) -
Wang Chenchen,
Zhao Wenyu,
Wu Xianqing,
Qu Jingping,
Chen Yifeng
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000537
Subject(s) - regioselectivity , chemistry , stereocenter , oxindole , palladium , aryne , intramolecular force , domino , catalysis , cascade reaction , combinatorial chemistry , medicinal chemistry , organic chemistry , enantioselective synthesis
A palladium‐catalyzed domino spiro‐cyclization of carbamoyl chlorides with alkynes and benzynes, involving intramolecular C−H activation to afford valuable oxindole scaffolds bearing spiro quaternary stereocenters, has been developed. This one‐step synthesis of spirooxindole is both step‐ and atom‐economic, proceeding with high regioselectivity in moderate to excellent yields.