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Synthesis of Diketopiperazine Scaffolds with Tailored N ‐ and α‐Chains by Selective Modification of Customizable Units
Author(s) -
Saavedra Carlos J.,
Cuevas Fernando,
RomeroEstudillo Ivan,
Boto Alicia
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000470
Subject(s) - chemistry , domino , scaffold , combinatorial chemistry , nanotechnology , process (computing) , organic chemistry , computer science , materials science , catalysis , database , operating system
The selective manipulation of Hyp customizable units in DKP substrates allows the generation of a rigid scaffold with four tailor‐made chains which are spatially‐orientated. The key step is a domino radical scission‐oxidation process which allows the generation of N ‐substituted DKPs. The versatility of this methodology to produce scaffolds in high optical purity for material and drug discovery is described herein.