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Silver(I)‐ and Base‐Mediated formal [4+3] Cycloaddition of in Situ generated 1,2‐Diaza‐1,3‐dienes with C,N ‐Cyclic Azomethine Imines: An Efficient Protocol for the Synthesis of Tetrazepine Derivatives
Author(s) -
Li Zefei,
Li Shuaikang,
Kan Tianjiao,
Wang Xinyue,
Xin Xin,
Hou Yunlei,
Gong Ping
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000398
Subject(s) - chemistry , cycloaddition , in situ , substrate (aquarium) , functional group , combinatorial chemistry , base (topology) , organic chemistry , catalysis , mathematical analysis , oceanography , polymer , mathematics , geology
A silver(I)‐ and base‐mediated formal [4+3] cycloaddition reaction of in situ generated 1,2‐diaza‐1,3‐dienes with in situ formed C,N ‐cyclic azomethine imines has been developed. This protocol provided an efficient method for the synthesis of biologically important 1,2,4,5‐tetrazepine derivatives with a wild substrate scope and excellent functional group tolerance in moderate to excellent yields.