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Cu(I)/KOH‐Promoted Condensation between o ‐Arylenediamines and Nitroarenes to Access 2‐Aryl‐2 H ‐Benzotriazoles
Author(s) -
Li HongChen,
Gao WenXia,
Huang XiaoBo,
Zhou YunBing,
Liu MiaoChang,
Wu HuaYue
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000397
Subject(s) - chemistry , aryl , condensation , ligand (biochemistry) , combinatorial chemistry , base (topology) , condensation reaction , medicinal chemistry , receptor , organic chemistry , catalysis , biochemistry , alkyl , physics , thermodynamics , mathematical analysis , mathematics
Reported is the condensation between o ‐arylenediamines and nitroarenes enabled by a cooperative action of acid and base, providing a direct entry to 2‐aryl‐2 H ‐benzotriazoles. The potential practicability of this methodology was demonstrated by 100 mmol‐scale reactions and the synthesis of serotonin/dopamine receptor ligand and human growth hormone.