Cu(I)/KOH‐Promoted Condensation between  o ‐Arylenediamines and Nitroarenes to Access 2‐Aryl‐2 H ‐Benzotriazoles | Zendy

Li HongChen | Zendy; Gao WenXia | Zendy; Huang XiaoBo | Zendy; Zhou YunBing | Zendy; Liu MiaoChang | Zendy; Wu HuaYue | Zendy

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Cu(I)/KOH‐Promoted Condensation between o ‐Arylenediamines and Nitroarenes to Access 2‐Aryl‐2 H ‐Benzotriazoles

Author(s) -

Li HongChen,

Gao WenXia,

Huang XiaoBo,

Zhou YunBing,

Liu MiaoChang,

Wu HuaYue

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202000397

Subject(s) - chemistry , aryl , condensation , ligand (biochemistry) , combinatorial chemistry , base (topology) , condensation reaction , medicinal chemistry , receptor , organic chemistry , catalysis , biochemistry , alkyl , physics , thermodynamics , mathematical analysis , mathematics

Reported is the condensation between o ‐arylenediamines and nitroarenes enabled by a cooperative action of acid and base, providing a direct entry to 2‐aryl‐2 H ‐benzotriazoles. The potential practicability of this methodology was demonstrated by 100 mmol‐scale reactions and the synthesis of serotonin/dopamine receptor ligand and human growth hormone.

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