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Cover Picture: Phosphoramidates as Transient Precursors of Nitrogen‐Centered Radical Under Visible‐Light Irradiation: Application to the Synthesis of Phthalazine Derivatives (Adv. Synth. Catal. 11/2020)
Author(s) -
De Abreu Maxime,
Selkti Mohamed,
Belmont Philippe,
Brachet Etienne
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000382
Subject(s) - chemistry , phthalazine , photochemistry , intramolecular force , irradiation , radical , medicinal chemistry , organic chemistry , physics , nuclear physics
The inside cover picture , phosphoramidates and especially phosphonohydrazones were, for the first time, used as efficient N‐Centered Radical (NCR) precursors under visible light irradiation. Mechanistic investigations confirmed the formation of an N‐radical from these brand new derivatives, which was able to be engaged in an intramolecular 6‐ exo‐dig cyclization to provide phthalazines. Compared to previous pre‐activated moieties, the phosphoramidate group is self‐immolative, thus enhancing its attractiveness for the C−N bond formation. Details of this work can be found in the full paper on pages 2217–2223 (M. De Abreu, M. Selkti, P. Belmont, E. Brachet, Adv. Synth. Catal . 2020 , 362 , 2217–2223; DOI: 10.1002/adsc.202000018).