Dirhodium(II)‐Catalyzed Cyclopropanation of Alkyne‐Containing α‐Diazoacetates for the Synthesis of Cycloalkynes | Zendy

Zeng Qian | Zendy; He Ciwang | Zendy; Zhou Su | Zendy; Dong Kuiyong | Zendy; Qiu Lihua | Zendy; Xu Xinfang | Zendy

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Dirhodium(II)‐Catalyzed Cyclopropanation of Alkyne‐Containing α‐Diazoacetates for the Synthesis of Cycloalkynes

Author(s) -

Zeng Qian,

He Ciwang,

Zhou Su,

Dong Kuiyong,

Qiu Lihua,

Xu Xinfang

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202000360

Subject(s) - cyclopropanation , cyclopropene , cyclopropane , intramolecular force , alkyne , chemistry , carbene , catalysis , aryl , combinatorial chemistry , medicinal chemistry , organic chemistry , ring (chemistry) , alkyl

An efficient dirhodium(II)‐catalyzed macrocyclization reaction of alkyne‐containing diazoacetates through intramolecular metal carbene cyclopropanation is described. This method provides a variety of 12‐ to 22‐membered macrocyclic alkynes, which incorporate ortho ‐aryl, cyclopropane, and cyclopropene units, in good to excellent yields under mild reaction conditions.

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