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Dirhodium(II)‐Catalyzed Cyclopropanation of Alkyne‐Containing α‐Diazoacetates for the Synthesis of Cycloalkynes
Author(s) -
Zeng Qian,
He Ciwang,
Zhou Su,
Dong Kuiyong,
Qiu Lihua,
Xu Xinfang
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000360
Subject(s) - cyclopropanation , cyclopropene , cyclopropane , intramolecular force , alkyne , chemistry , carbene , catalysis , aryl , combinatorial chemistry , medicinal chemistry , organic chemistry , ring (chemistry) , alkyl
An efficient dirhodium(II)‐catalyzed macrocyclization reaction of alkyne‐containing diazoacetates through intramolecular metal carbene cyclopropanation is described. This method provides a variety of 12‐ to 22‐membered macrocyclic alkynes, which incorporate ortho ‐aryl, cyclopropane, and cyclopropene units, in good to excellent yields under mild reaction conditions.