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Synthesis of 2‐(Arylthio)indolenines via Chemoselective Arylation of Thio‐Oxindoles with Arynes
Author(s) -
Saputra Adi,
Fan Rong,
Yao Tuanli,
Chen Jian,
Tan Jiajing
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000308
Subject(s) - aryne , chemistry , thio , chemoselectivity , combinatorial chemistry , scope (computer science) , reaction conditions , protocol (science) , scalability , functional group , substrate (aquarium) , organic chemistry , computer science , catalysis , programming language , database , medicine , polymer , alternative medicine , oceanography , pathology , geology
A chemoselective S‐ arylation reaction of thio‐oxindoles with arynes is presented. The reaction was performed under mild conditions and provided a straightforward synthesis of 2‐(arylthio)indolenines in good to excellent yields. Besides, this simple operational protocol is not only scalable but also has good functional group compatibilities and substrate scope. Thus, our protocol should allow for the expansion of chemical space via developing new scaffolds of thioimidates that are difficult to synthesize otherwise.