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Visible‐Light‐Induced Radical Defluoroborylation of Trifluoromethyl Alkenes: An Access to gem ‐Difluoroallylboranes
Author(s) -
Chen Guojun,
Wang Liling,
Liu Xiaozu,
Liu Peijun
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000257
Subject(s) - chemistry , trifluoromethyl , boranes , trifluoromethylation , carbene , surface modification , molecule , photoredox catalysis , radical , visible spectrum , combinatorial chemistry , photochemistry , catalysis , organic chemistry , boron , photocatalysis , alkyl , physics , optoelectronics
A photoredox‐catalyzed defluoroborylation of trifluoromethyl alkenes with N ‐heterocyclic carbene boranes is described for the synthesis of gem ‐difluoroallylboranes. This protocol exhibits a broad substrate scope and good functional group compatibility, which enables the late‐stage functionalization of structurally complex compounds. Further transformations of the defluoroborylation products to valuable CF 2 ‐containing molecules are also demonstrated.