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Catalytic Asymmetric Synthesis of Isochroman Derivatives
Author(s) -
Kumar Mukesh,
Joshi Kavita,
Chauhan Pankaj
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000243
Subject(s) - chemistry , catalysis , combinatorial chemistry , stereoselectivity , enantioselective synthesis , organocatalysis , organic chemistry
The isochroman scaffold constitutes an important structural unit, which is present in various bioactive natural products and synthetic pharmaceutical compounds exhibiting wide arrays of biological properties. Hence the synthesis of this class of heterocyclic compounds in a stereoselective fashion is highly significant and desirable. In the last decade, a substantial advancement has been witnessed ln the catalytic asymmetric synthesis of isochroman derivatives by employing metal catalysts bearing chiral ligands or by chiral metal‐free organocatalysts. This review aims to provide an overview of the transition metal‐catalyzed and organocatalyzed asymmetric syntheses of isochroman derivatives including isochromenes and isochromanones.