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Scalable Electrochemical Transition‐Metal‐Free Dehydrogenative Cross‐Coupling Amination Enabled Alkaloid Clausines Synthesis
Author(s) -
Zhang Pan,
Li Baoying,
Niu Liwei,
Wang Ling,
Zhang Guofeng,
Jia Xiaofei,
Zhang Guoying,
Liu Siyuan,
Ma Li,
Gao Wei,
Qin Dawei,
Chen Jianbin
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000228
Subject(s) - chemistry , amination , moiety , transition metal , electrochemistry , combinatorial chemistry , carbazole , ionic bonding , organic chemistry , catalysis , ion , electrode
Reported herein is an environmentally benign electrochemical C−H bond dehydrogenative amination protocol for the construction of privileged carbazole moiety with broad generality. Preliminary mechanistic investigations implied a radical reaction pathway. Compared with traditional ionic routes, the scalable transition‐metal and exogenous‐oxidant free strategy highlighted the green and sustainable nature of this method.