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Direct α‐Arylation of Alcohols with Aryl Halides through a Radical Chain Mechanism
Author(s) -
Aoki Kohei,
Yonekura Kyohei,
Ikeda Yuko,
Ueno Ryota,
Shirakawa Eiji
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000216
Subject(s) - chemistry , homolysis , halide , aryl , mechanism (biology) , medicinal chemistry , aryl radical , base (topology) , organic chemistry , photochemistry , radical , alkyl , philosophy , epistemology , mathematical analysis , mathematics
Alcohols were found to be arylated directly at their α‐C−H bond with aryl halides in the presence of a base and a substoichiometric amount of t ‐BuOO t ‐Bu through a homolytic aromatic substitution mechanism.
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