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Free‐Radical‐Promoted Alkenylation of C( sp 3 )−H Bond in Chloroalkane with Cinnamic Acid and β ‐Nitrostyrene
Author(s) -
Sun Minzhi,
Xu Zhengbao,
Li Wenjie,
Yang Le,
You Huichao,
Yu Dan,
Fang Fang,
Wang Yaxin,
Liu ZhongQuan
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000215
Subject(s) - chemistry , cinnamic acid , double bond , halogen , free radical addition , medicinal chemistry , polymer chemistry , stereochemistry , organic chemistry , alkyl
We demonstrated herein a free‐radical alkenylation of the C( sp 3 )−H bond in 1,2‐dichloroethane with cinnamic acid and β ‐nitrostyrene. This method not only provides a facile approach to chloroalkylated styrenes, but also would be instructive for halogen‐atom directing selective functionalization of inert C( sp 3 )−H bond.