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A Copper‐Catalyzed Sonogashira Coupling Reaction of Diverse Activated Alkyl Halides with Terminal Alkynes Under Ambient Conditions
Author(s) -
Cao YuXi,
Dong XiaoYang,
Yang Jun,
Jiang ShengPeng,
Zhou Shuangliu,
Li ZhongLiang,
Chen GuoQiang,
Liu XinYuan
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000189
Subject(s) - chemistry , sonogashira coupling , halide , alkyl , catalysis , copper , alkyne , ligand (biochemistry) , coupling reaction , bromide , combinatorial chemistry , organic chemistry , medicinal chemistry , palladium , biochemistry , receptor
We describe a copper‐catalyzed Sonogashira coupling reaction of alkyl halides with terminal alkynes under ambient conditions, efficiently providing a versatile tool for the construction of substituted alkynes. A new proline‐based N,N,P‐ligand is utilized to promote the transformation under a mild reaction condition. Diverse alkyl halides, such as primary and secondary (hetero)benzyl chlorides and bromides, secondary and tertiary α‐bromo amides and propargylic bromide, are applicable to provide a wide array of alkynes.
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