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Front Cover Picture: Catalytic Intramolecular Coupling of Ketoalkenes by Allylic C( sp 3 )−H Bond Cleavage: Synthesis of Five‐ and Six‐Membered Carbocyclic Compounds (Adv. Synth. Catal. 6/2020)
Author(s) -
Mita Tsuyoshi,
Uchiyama Masashi,
Sato Yoshihiro
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000184
Subject(s) - chemistry , intramolecular force , allylic rearrangement , front cover , stereochemistry , cleavage (geology) , bond cleavage , xantphos , catalysis , medicinal chemistry , palladium , cover (algebra) , organic chemistry , mechanical engineering , geotechnical engineering , fracture (geology) , engineering
The front cover picture was provided by Tsuyoshi Mita and co‐authors. They revealed that various ketoalkenes underwent a Co‐catalyzed intramolecular cyclization reaction triggered by cleavage of the allylic C( sp 3 )–H bond, affording carbocyclic compounds with high regio‐ and diastereoselectivity. This picture represents that ketoalkenes are automatically converted to tramadol, a novel pain drug, by a “Co‐Xantphos factory”. This paper is dedicated to our scientific hero, Professor Eric N. Jacobsen on the occasion of his 60 th birthday. Further details of this work can be found in the communication on pages 1275–1280 (T. Mita, M. Uchiyama, Y. Sato, Adv. Synth. Catal . 2020 , 362 , 1275–1280; DOI: 10.1002/adsc.201901533).).