Premium
Electrochemical Dearomative Dihydroxylation and Hydroxycyclization of Indoles
Author(s) -
Wu Ju,
Guillot Régis,
Kouklovsky Cyrille,
Vincent Guillaume
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000158
Subject(s) - dihydroxylation , indole test , redox , electrochemistry , chemistry , mediator , combinatorial chemistry , hydroxylation , organic chemistry , electrode , biology , enantioselective synthesis , enzyme , catalysis , endocrinology
We describe a simple and sustainable MgBr 2 ‐mediated electrochemical dearomative dihydroxylation and hydroxycyclization reactions of indoles with water. MgBr 2 is used in substoichiometric amount and acts as an electrolyte and potentially as a redox mediator to indirectly oxidize the indole nucleus into a bromonium ion which is involved in the aforementioned reactions.