Bifunctional Phosphonium Salt‐catalyzed Enantioselective [4+2] Annulation of Isoindigos with Allenes: Access to Complex Heterocycles with Centerpiece of 4 H ‐Pyrans | Zendy

Du Juan | Zendy; Wu JiaHong | Zendy; Zhu Lixiang | Zendy; Ren Xiaoyu | Zendy; Jiang Chunhui | Zendy; Wang Tianli | Zendy

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Bifunctional Phosphonium Salt‐catalyzed Enantioselective [4+2] Annulation of Isoindigos with Allenes: Access to Complex Heterocycles with Centerpiece of 4 H ‐Pyrans

Author(s) -

Du Juan,

Wu JiaHong,

Zhu Lixiang,

Ren Xiaoyu,

Jiang Chunhui,

Wang Tianli

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202000150

Subject(s) - bifunctional , chemistry , annulation , enantioselective synthesis , phosphonium , phosphonium salt , catalysis , pyran , salt (chemistry) , stereoselectivity , combinatorial chemistry , organocatalysis , organic chemistry , stereochemistry

Structurally fused heterocycles encompassing 4 H ‐pyran centerpiece are prevalent scaffolds with promising biological activities, but have daunting synthetic challenges. Herein, we presented a regio‐ and stereoselective [4+2] annulation of isoindigo derivatives with allenes by bifunctional phosphonium catalysis. This protocol provides a complementary way for accessing complex heterocyclic compounds.

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