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Bifunctional Phosphonium Salt‐catalyzed Enantioselective [4+2] Annulation of Isoindigos with Allenes: Access to Complex Heterocycles with Centerpiece of 4 H ‐Pyrans
Author(s) -
Du Juan,
Wu JiaHong,
Zhu Lixiang,
Ren Xiaoyu,
Jiang Chunhui,
Wang Tianli
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000150
Subject(s) - bifunctional , chemistry , annulation , enantioselective synthesis , phosphonium , phosphonium salt , catalysis , pyran , salt (chemistry) , stereoselectivity , combinatorial chemistry , organocatalysis , organic chemistry , stereochemistry
Structurally fused heterocycles encompassing 4 H ‐pyran centerpiece are prevalent scaffolds with promising biological activities, but have daunting synthetic challenges. Herein, we presented a regio‐ and stereoselective [4+2] annulation of isoindigo derivatives with allenes by bifunctional phosphonium catalysis. This protocol provides a complementary way for accessing complex heterocyclic compounds.