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Asymmetric Catalytic 1,2‐Dihydrophosphination of Secondary 1,2‐Diphosphines – Direct Access to Free P *‐ and P *, C *‐Diphosphines
Author(s) -
Teo Ronald Hong Xiang,
Chen Houguang Jeremy,
Li Yongxin,
Pullarkat Sumod A.,
Leung PakHing
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000131
Subject(s) - diphosphines , chemistry , diastereomer , catalysis , palladium , medicinal chemistry , stereochemistry , organic chemistry
A 1,2‐dihydrophosphination of bis(phenylphosphino)ethane with a wide range of activated olefins was achieved in a catalytic manner with enantiomeric and diastereomeric excess of up to >99% and 44% respectively. The protocol can be extended to selected substrates leading to free P ‐ and C ‐chiral 1,2‐diphosphines. The synthesized ligands can also undergo direct complexation onto palladium affording complexes with complete retention of stereo‐integrity.