Synthesis of [3.4]‐Spirooxindoles through Cascade Carbopalladation of Skipped Dienes | Zendy

Azizollahi Hamid | Zendy; PérezGómez Marta | Zendy; Mehta Vaibhav P. | Zendy; GarcíaLópez JoséAntonio | Zendy

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Synthesis of [3.4]‐Spirooxindoles through Cascade Carbopalladation of Skipped Dienes

Author(s) -

Azizollahi Hamid,

PérezGómez Marta,

Mehta Vaibhav P.,

GarcíaLópez JoséAntonio

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202000111

Subject(s) - chemistry , cascade , ring (chemistry) , cascade reaction , double bond , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , chromatography

A synthetic route to [3.4]‐spirooxindoles based on cascade carbopalladation reactions of 1,4‐dienes is described. While carbopalladation of alkenes have been used to access mainly [4.4]‐ or [4.5]‐spirocycles, 4‐ exo ‐ trig carbopalladation has not been yet applied to the synthesis of relevant [3.4]‐spirooxindole scaffolds bearing a cyclobutyl ring. In addition, the cascade reaction generates an exocyclic double bond that can serve as a platform to further diversify the substitution pattern of the spirooxindole nuclei.

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