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Catalytic Asymmetric Mannich‐Type Reaction of Malononitrile with N‐Boc α‐Ketiminoesters Using Chiral Organic Base Catalyst with Halogen Bond Donor Functionality
Author(s) -
Kuwano Satoru,
Nishida Yuki,
Suzuki Takumi,
Arai Takayoshi
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000092
Subject(s) - malononitrile , chemistry , catalysis , halogen , base (topology) , organocatalysis , organic chemistry , enantioselective synthesis , halogen bond , combinatorial chemistry , medicinal chemistry , mathematical analysis , alkyl , mathematics
Chiral organic base catalyst with halogen bond donor functionality catalyzed asymmetric Mannich‐type reaction of malononitrile with α‐ketiminoesters to produce α,α‐disubstituted α‐amino acid derivatives in good yields with high enantioselectivities. The malononitrile‐derived amino acid was smoothly transformed to chiral aminomalonate without loss of ee.