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Enantioselective Dearomative Cyclization of Homotryptamines with Allenamides into Indolo[2,3‐ b ]quinolines
Author(s) -
Biswas Soumen,
Kim Hanbyul,
Le Anh Cao Kiet,
Shin Seunghoon
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000083
Subject(s) - chemistry , enantioselective synthesis , quinoline , catalysis , combinatorial chemistry , organocatalysis , phosphoric acid , stereochemistry , organic chemistry
We have developed a catalytic asymmetric dearomative cyclization of homotryptamine derivatives, furnishing enantioenriched indolo[2,3‐ b ]quinoline scaffolds. The activation of allenamides in the presence of chiral phosphoric acids triggered the dearomative cyclization in up to 99% ee.