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Mild and Regioselective Three‐component Heteroarylation‐Nitration of Alkenes with Imidazo[1,2‐ a ]pyridines and tert ‐Butyl Nitrite
Author(s) -
Zhang Jie,
Xie Shentong,
Liu Ping,
Sun Peipei
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000078
Subject(s) - nitration , regioselectivity , chemistry , nitrite , pyridine , nitro , catalysis , component (thermodynamics) , organic chemistry , medicinal chemistry , combinatorial chemistry , nitrate , alkyl , physics , thermodynamics
An efficient and regioselective three‐component heteroarylation‐nitration of alkenes with imidazo[1,2‐ a ]pyridines and tert ‐butyl nitrite has been developed. The process tolerants a variety of functional groups under mild conditions in the absence of catalysts and additives to give nitro functionalized imidazo[1,2‐ a ]pyridine derivatives in moderate to good yields. The reaction is also applicable for some other aza‐heterocycles.