Dimethyl Sulfoxide as an Oxygen Atom Source Enabled Tandem Conversion of 2‐Alkynyl Carbonyls to 1,2‐Dicarbonyls | Zendy

Lu Yuan | Zendy; Luo MuJia | Zendy; Hu Ming | Zendy; Li Yang | Zendy; Li JinHeng | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Dimethyl Sulfoxide as an Oxygen Atom Source Enabled Tandem Conversion of 2‐Alkynyl Carbonyls to 1,2‐Dicarbonyls

Author(s) -

Lu Yuan,

Luo MuJia,

Hu Ming,

Li Yang,

Li JinHeng

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202000066

Subject(s) - chemistry , tandem , nucleophile , oxygen atom , medicinal chemistry , dimethyl sulfoxide , nucleophilic addition , cleavage (geology) , oxygen , photochemistry , bond cleavage , combinatorial chemistry , molecule , catalysis , organic chemistry , materials science , geotechnical engineering , fracture (geology) , engineering , composite material

A tandem transformation of 2‐alkynyl carbonyl compounds by means of a CuBr 2 /I 2 /DMSO/water system is developed, enabling the fromation of various functionalized 1,2‐dicarbonyl compounds, including 1,2‐diketones, α ‐keto amides and α‐keto ester. This Cu‐promoted iodine‐mediated tandem procedure employs DMSO as the oxygen atom source of the formed carbonyl group through iodonium ion formation, nucleophilic DMSO addition and C−C bond cleavage cascades.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research