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An Addition of Terminal Alkynes to Phthalazin‐2‐Ium Bromide Catalyzed by Copper
Author(s) -
Chen Qian,
Luo Mingjian,
Guo Fang,
Liang Kun,
Zhou Fanrui,
Gao Guolin
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000053
Subject(s) - chemistry , copper , catalysis , bromide , alkyl , ligand (biochemistry) , scope (computer science) , medicinal chemistry , combinatorial chemistry , organic chemistry , receptor , computer science , biochemistry , programming language
A copper‐catalyzed addition of alkynes to phthalazin‐2‐ium bromide has been developed under mild conditions, leading to the production of propargylamines analogues. The addition products of a broad scope of phthalazin‐2‐ium bromides bearing various N ‐benzyl or alkyl can be obtained in good to high yields. Moderate enantioselectivity was observed in preliminary screening studies of chiral organic ligand.