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Oxidative Radical Relay Functionalization for the Synthesis of Benzimidazo[2,1‐ a ]iso‐quinolin‐6(5 H )‐ones
Author(s) -
Sun Kai,
Li Guofeng,
Li Yuyang,
Yu Jie,
Zhao Qing,
Zhang Zhiguo,
Zhang Guisheng
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000040
Subject(s) - chemistry , isoquinoline , functional group , oxidative phosphorylation , scope (computer science) , relay , combinatorial chemistry , radical , substrate (aquarium) , surface modification , organic chemistry , biochemistry , power (physics) , physics , quantum mechanics , oceanography , computer science , programming language , geology , polymer
Here, a mild and general oxidative radical relay carbocyclization reaction with 2‐arylbenzoimidazoles and cyclic ethers is reported. This method provides an efficient access to a wide range of structurally diverse benzimidazo[2,1‐ a ]isoquinoline‐6(5 H )‐ones under metal‐free conditions. The wide substrate scope, good functional group tolerance, and scale‐up operation of this method are expected to promote its potential applications in biotechnology and pharmacy.