Selective Formation of 2‐(2‐Aminophenyl)benzothiazoles via Copper‐Catalyzed Aerobic C−C Bond Cleavage of Isatins | Zendy

Wang Hongfen | Zendy; Xu Zhenhua | Zendy; Deng GuoJun | Zendy; Huang Huawen | Zendy

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Selective Formation of 2‐(2‐Aminophenyl)benzothiazoles via Copper‐Catalyzed Aerobic C−C Bond Cleavage of Isatins

Author(s) -

Wang Hongfen,

Xu Zhenhua,

Deng GuoJun,

Huang Huawen

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201901670

Subject(s) - chemistry , morpholine , cleavage (geology) , catalysis , bond cleavage , combinatorial chemistry , copper , medicinal chemistry , stereochemistry , organic chemistry , geotechnical engineering , fracture (geology) , engineering

Herein, two kinds of structurally significant 2‐(2‐aminophenyl)benzothiazoles were selectively generated by the copper‐catalyzed aerobic C−C bond cleavage of isatins. Morpholine served not only as a reactant but a promoter in the three‐component assembly of 2‐(2‐aminophenyl)benzothiazoles. Also it proved to be an efficient additive for the formation of free amino 2‐(2‐aminophenyl)benzothiazoles. This protocol represents a step‐economic entry to the title compounds with a range of compatible functionalities.

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