Enantioselective Vinylogous Mannich‐Type Reactions to Construct CF 3 S‐Containing Stereocenters Catalysed by Chiral Quaternary Phosphonium Salts

A series of benzyl trifluoromethyl sulphides bearing a nitro group were utilized as CF 3 S‐containing building blocks to construct chiral CF 3 S‐containing molecules via enantioselective vinylogous Mannich‐type reactions. In such reactions, high yields and enantioselectivities were obtained using chiral quaternary phosphonium salts derived from amino acids. Moreover, a chiral cyclic urea bearing the CF 3 S moiety was obtained from further transformation of the product.