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Nickel/NHC‐Catalyzed Enantioselective Cyclization of Pyridones and Pyrimidones with Tethered Alkenes
Author(s) -
Shen Di,
Zhang WuBin,
Li Zhiyang,
Shi ShiLiang,
Xu Youjun
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901582
Subject(s) - enantioselective synthesis , chemistry , catalysis , annulation , nickel , bicyclic molecule , combinatorial chemistry , ligand (biochemistry) , organic chemistry , receptor , biochemistry
Reported is a highly enantioselective Ni(0)‐catalyzed endo ‐selective C−H annulation of 2‐ and 4‐pyridone, and 4‐pyrimidone with alkenes to provide drug‐relevant bicyclic heterocycle products. The use of a readily prepared chiral bulky NHC ligand (SIPE) for Ni catalyst and commercially available AlEt 3 as co‐catalyst enhanced the practicality of this reaction.