Nickel/NHC‐Catalyzed Enantioselective Cyclization of Pyridones and Pyrimidones with Tethered Alkenes | Zendy

Shen Di | Zendy; Zhang WuBin | Zendy; Li Zhiyang | Zendy; Shi ShiLiang | Zendy; Xu Youjun | Zendy

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Nickel/NHC‐Catalyzed Enantioselective Cyclization of Pyridones and Pyrimidones with Tethered Alkenes

Author(s) -

Shen Di,

Zhang WuBin,

Li Zhiyang,

Shi ShiLiang,

Xu Youjun

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201901582

Subject(s) - enantioselective synthesis , chemistry , catalysis , annulation , nickel , bicyclic molecule , combinatorial chemistry , ligand (biochemistry) , organic chemistry , receptor , biochemistry

Reported is a highly enantioselective Ni(0)‐catalyzed endo ‐selective C−H annulation of 2‐ and 4‐pyridone, and 4‐pyrimidone with alkenes to provide drug‐relevant bicyclic heterocycle products. The use of a readily prepared chiral bulky NHC ligand (SIPE) for Ni catalyst and commercially available AlEt 3 as co‐catalyst enhanced the practicality of this reaction.

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