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From Phenylhydrazone to 1 H ‐1,2,4‐Triazoles via Nitrification, Reduction and Cyclization
Author(s) -
Hao Liqiang,
Wang Guodong,
Sun Jian,
Xu Jun,
Li Hongshuang,
Duan Guiyun,
Xia Chengcai,
Zhang Pengfei
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901563
Subject(s) - chemistry , annulation , tandem , solvent , combinatorial chemistry , reduction (mathematics) , dichloroethane , nitrification , organic chemistry , medicinal chemistry , catalysis , nitrogen , materials science , composite material , geometry , mathematics
Herein we report an annulation of phenylhydrazone via a tandem nitrification, reduction, cyclization protocol employing cobalt nitrate and 1,2‐dichloroethane to produce substituted 1 H ‐1,2,4‐triazoles. Notably, 1,2‐dichloroethane serves both the solvent and a hydrogen source for transfer hydrogenation. This methodology works under mild conditions, providing a direct approach for the synthesis of 1 H ‐1,2,4‐triazoles.