Premium
Photo‐Mediated Decarboxylative Ketonization of Atropic Acids with Sulfonyl Hydrazides: Direct Access to β ‐Ketosulfones
Author(s) -
Chen Jie,
Allyson Zoe G.,
Xin JingRui,
Guan Zhi,
He YanHong
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901525
Subject(s) - chemistry , sulfonyl , decarboxylation , combinatorial chemistry , molecular oxygen , catalysis , organic chemistry , alkyl
An efficient formation of synthetically and biologically relevant β ‐ketosulfones via a photo‐mediated decarboxylative ketonization of atropic acids was disclosed. The approach features metal‐free conditions, good functional group compatibility, readily available starting materials and the use of ubiquitous dioxygen as both oxygen source and oxidant. Furthermore, mechanistic studies reveal that the decarboxylative ketonization reaction proceeds via a radical mechanism and may involve a radical chain reaction.