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Versatile Catalytic Reactions of Norbornadiene Derivatives with Alkynes
Author(s) -
Khan Ruhima,
Chen Jingchao,
Fan Baomin
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901494
Subject(s) - norbornadiene , chemistry , cycloaddition , catalysis , combinatorial chemistry , organic synthesis , alkynylation , triple bond , ring (chemistry) , tandem , atom economy , organic chemistry , double bond , materials science , composite material
Norbornadiene and its derivatives are important synthetic intermediates and useful building blocks in organic synthesis as they can serve as a general template to create highly substituted ring systems with high atom economy. Alkynes have always been one of the most important functional groups in organic chemistry because of their rigidity, electronic properties and numerous methods available for functionalization of the triple bond. The different kinds of reaction between these two classes of compounds, norbornadienes and alkynes, provide useful methods for the synthesis of various important compounds/frameworks, indicating the utility of these reactions in chemical synthesis. Indeed, norbornadienes undergo various reactions with alkynes – alkynylation, ring‐opening, cyclization, cycloaddition, Pauson–Khand and other tandem reactions. This review provides an overview of the achievements in the various reactions between norbornadiene and its derivatives with alkynes.