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Front Cover Picture: γ ‐Functionalization of α,β ‐Unsaturated Nitriles under Mild Conditions: Versatile Synthesis of 4‐Aryl‐2‐Bromopyridines (Adv. Synth. Catal. 23/2019)
Author(s) -
Sim Jaeuk,
Viji Mayavan,
Rhee Jeongtae,
Jo Hyeju,
Cho Suk Joon,
Park Yunjeong,
Seo SeungYong,
Jung KwanYoung,
Lee Heesoon,
Jung JaeKyung
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901430
Subject(s) - chemistry , enamine , aryl , front cover , surface modification , reagent , stereochemistry , medicinal chemistry , cover (algebra) , organic chemistry , catalysis , alkyl , engineering , mechanical engineering
The front cover picture , designed by Jaeuk Sim from the group of Heesoon Lee and Jae‐Kyung Jung, illustrates the synthesis of 4‐aryl‐2‐halopyridines via γ ‐functionalization of α,β ‐unsaturated nitriles. Our method features enamine formation at the γ ‐position of vinylogous nitriles followed by cyclization to heteroaromatics. In commemoration of Christmas, this picture depicts the reagents gathered around the Christmas tree to create diverse heterocycles through the enamine intermediates. Details of this work can be found in the Update on pages 5458–5465 (J. Sim, M. Viji, J. Rhee, H. Jo, S. J. Cho, Y. Park, S.‐Y. Seo, K.‐Y. Jung, H. Lee, J.‐K. Jung, Adv. Synth. Catal . 2019 , 361 , 5458–5465; DOI: 10.1002/adsc.201901002).