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Three‐Component Reaction of p ‐Quinone Monoacetals, Amines and Diarylphosphine Oxides to Afford m‐ (Phosphinyl)anilides
Author(s) -
Shen Ruwei,
Wang Xin,
Zhang Shunlin,
Dong Chao,
Zhu Dunru,
Han LiBiao
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901421
Subject(s) - chemistry , quinone , nucleophile , amine gas treating , component (thermodynamics) , acetal , enone , condensation , medicinal chemistry , nucleophilic addition , photochemistry , organic chemistry , catalysis , physics , thermodynamics
The three‐component reaction of p ‐quinone monoacetals, amines and diarylphosphine oxides is developed to afford m‐ (diarylphosphinyl)anilides in moderate to high yields. The reaction may proceed via a process involving phospha‐nucleophilic addition to an iminoquinone acetal intermediate and/or carbonyl‐amine condensation with a phosphinyl enone intermediate.