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Synthesis of Tetrahydropyridazines via Pd‐Catalyzed Carboamination of Alkenyl Hydrazones
Author(s) -
Guo Yajing,
Zhao Jinbo,
Zhang Qian
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901378
Subject(s) - chemistry , enantioselective synthesis , aryl , catalysis , halide , scaffold , combinatorial chemistry , organic chemistry , medicine , alkyl , biomedical engineering
We report herein a facile approach to tetrahydropyridazines, a scaffold found in many natural products and biologically active entities, via Pd‐catalyzed carboamination of readily available alkenyl hydrazones with aryl and alkenyl halides. Preliminary studies showed its promise for enantioselective synthesis. This work offers an expedient access to the tetrahydropyridazine scaffold bearing substitution patterns, thus significantly increasing the availability of these derivatives for downstream evaluation.