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Controllable Synthesis of Polyheterocyclic Spirooxindoles and 3,3‐Bistryptophol Oxindoles via Fe(ClO 4 ) 3 ⋅ 6H 2 O‐Promoted Hetero‐Pictet‐Spengler Reaction
Author(s) -
Song JunRong,
Li ZhiYao,
Wang GuangDi,
Zhang Ni,
Chen Chao,
Chen Juan,
Ren Hai,
Pan Weidong
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901346
Subject(s) - chemistry , catalysis , perchloric acid , yield (engineering) , combinatorial chemistry , hydrolysis , reaction conditions , organic chemistry , materials science , metallurgy
An efficient Fe(ClO 4 ) 3 ⋅ 6H 2 O‐promoted hetero‐Pictet‐Spengler reaction has been developed, enabling divergent approaches to plenty of structurally diverse polyheterocyclic spirooxindoles and 3,3‐bistryptophol oxindoles from readily available isatins and substituted aromatic heterocyclic derivatives in up to 98% yield. Mechanistic investigation reveals that the perchloric acid generated upon on hydrolysis of Fe(ClO 4 ) 3 ⋅ 6H 2 O by residual water was the real catalyst. The synthetic robustness of this transformation is demonstrated by the friendly, easy handling of the catalyst and the controllable access of diverse privileged heterocyclic skeletons.