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Radical‐Cation‐Induced Crossed [2+2] Cycloaddition of Electron‐Deficient Anetholes Initiated by Iron(III) Salt
Author(s) -
Horibe Takahiro,
Katagiri Kei,
Ishihara Kazuaki
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901337
Subject(s) - chemistry , cycloaddition , salt (chemistry) , electron , radical ion , photochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , ion , physics , quantum mechanics
Radical cation‐induced crossed [2+2] cycloaddition of electron‐deficient anetholes was developed with the use of Fe(OTf) 3 as an initiator. Various 1,2‐diarylcyclobutanes can be synthesized in high yields with high diastereoselectivity from electron‐deficient anetholes, which have been less explored using conventional methods. This practical reaction system can be used for a decagram‐scale reaction (12 gram), in which the resulting product can be transformed to 1,2‐dicarbonyl compounds.