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Iridium‐Catalyzed Cycloisomerization of Alkynoic Acids: Synthesis of Unsaturated Lactones
Author(s) -
Huang Yi,
Zhang Xianghe,
Dong XiuQin,
Zhang Xumu
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901322
Subject(s) - cycloisomerization , iridium , chemistry , yield (engineering) , catalysis , indole test , combinatorial chemistry , organic chemistry , materials science , metallurgy
The iridium‐catalyzed cycloisomerization of various alkynoic acids was successfully developed, and a series of five‐, six‐, and especially seven‐membered unsaturated lactones were constructed with moderate yields and excellent regioselectivities (up to 68% yield, >99:1 rr). In addition, the indole compound can be easily prepared with 75% yield through this efficient synthetic methodology. Moreover, a plausible mechanism for this Ir‐catalyzed cycloisomerization of alkynoic acids was proposed.