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Mn(III)‐Mediated Regioselective 6‐ endo ‐trig Radical Cyclization of o ‐Vinylaryl Isocyanides to Access 2‐Functionalized Quinolines
Author(s) -
Liu Yan,
Li ShiJun,
Chen XiaoLan,
Fan LuLu,
Li XiaoYun,
Zhu ShanShan,
Qu LingBo,
Yu Bing
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901300
Subject(s) - chemistry , regioselectivity , quinoline , radical cyclization , diphenylphosphine , aryl , medicinal chemistry , radical , aryl radical , isocyanide , combinatorial chemistry , organic chemistry , catalysis , phosphine , alkyl
A Mn(III)‐mediated radical cyclization reaction of o ‐vinylaryl isocyanides and arylboronic acids or diphenylphosphine oxides to access various 2‐functionalized quinolines under mild conditions was developed. With the introduction of radical stabilizing substituents (e. g. aryl and methyl group) on vinyl group, this reaction provides a regiospecific 6‐ endo ‐trig radical cyclization of o ‐vinylaryl isocyanides, giving a number of structurally unique and biologically potential 2‐functionalized quinoline derivatives.