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Electrochemical Synthesis of 1,2,4‐Thiadiazoles through Intermolecular Dehydrogenative S‐N Coupling
Author(s) -
Li JiangSheng,
Xie XinYun,
Yang PanPan,
Jiang Si,
Tao Li,
Li ZhiWei,
Lu CuiHong,
Liu WeiDong
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901290
Subject(s) - chemistry , thiadiazoles , intermolecular force , electrochemistry , electrolysis , catalysis , electrolyte , combinatorial chemistry , photochemistry , organic chemistry , polymer chemistry , molecule , electrode
Abstract An electrochemical intermolecular dehydrogenative coupling reaction of isothiocyanates with 2‐aminopyridines/amidines was developed. Using n ‐Bu 4 NI as the catalyst and electrolyte, 1,2,4‐thiadiazoles and pyrido‐fused 1,2,4‐thiadiazoles were readily accessed with good to excellent efficiency under the undivided electrolysis conditions. This electrochemical approach obviates the use of external oxidants and transition‐metal catalysts.