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Diastereoselective Synthesis of Z‐Alkenyl Disulfides from α‐Thiophosphorylated Ketones and Thiosulfonates
Author(s) -
Musiejuk Mateusz,
Doroszuk Justyna,
Jędrzejewski Bartosz,
Ortiz Nieto Gregory,
Marin Navarro Marisol,
Witt Dariusz
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901208
Subject(s) - chemistry , base (topology) , combinatorial chemistry , reaction conditions , bearing (navigation) , organic chemistry , stereochemistry , polymer chemistry , catalysis , mathematical analysis , mathematics , cartography , geography
We developed a simple and efficient method for the synthesis of functionalized unsymmetrical Z ‐alkenyl disulfides under mild conditions in moderate to good yields. The designed method is based on the reaction of α‐thiophosphorylated carbonyl compounds with thiotosylates in the presence of a base. The developed method allows the preparation of unsymmetrical Z ‐alkenyl disulfides bearing additional hydroxy, carboxy, or ester functionalities