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Iron Catalyzed Synthesis of Pyrimidines Under Air
Author(s) -
Mondal Rakesh,
Sinha Suman,
Das Siuli,
Chakraborty Gargi,
Paul Nanda D.
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901172
Subject(s) - chemistry , catalysis , ligand (biochemistry) , primary (astronomy) , surface modification , combinatorial chemistry , redox , phenanthroline , organic chemistry , biochemistry , physics , receptor , astronomy
Herein we report an iron‐catalyzed multicomponent dehydrogenative functionalization of alcohols to pyrimidines under atmospheric conditions. Using a well‐defined Fe(II)‐complex featuring redox noninnocent 2‐phenylazo‐(1,10‐phenanthroline) ligand, as a catalyst, a wide array of 2,4,6‐trisubstituted pyrimidines were prepared via dehydrogenative coupling of primary and secondary alcohols with amidines under air at 100 °C. A few control experiments were carried out to understand and unveil the plausible reaction mechanism.