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LiBr‐Promoted Photoredox Minisci‐Type Alkylations of Quinolines with Ethers
Author(s) -
Wang Zhongzhen,
Ji Xiaochen,
Han Tonghao,
Deng GuoJun,
Huang Huawen
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901168
Subject(s) - chemistry , alkylation , reagent , photoredox catalysis , bromide , combinatorial chemistry , catalysis , photochemistry , organic chemistry , photocatalysis
A visible‐light‐mediated photoredox Minisci‐type alkylation with ethers as the alkylating reagent is reported. User‐friendly LiBr has been found to be the key promoter for this radical coupling. The reaction exhibits broad functional group tolerance for both C2 and C4 couplings/alkylations of quinolines. Mechanistic studies suggest that the bromide additive could not only dramatically enhance the reaction but also alter the reaction mechanism probably over a reductive catalytic cycle.