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Metal‐Free C3 Hydroxylation of Quinoxalin‐2(1 H )‐ones in Water
Author(s) -
Peng Sha,
Hu Die,
Hu JiaLi,
Lin YingWu,
Tang ShanShan,
Tang HaiShan,
He JunYi,
Cao Zhong,
He WeiMin
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901163
Subject(s) - chemistry , hydroxylation , quinoxaline , recrystallization (geology) , metal , stereochemistry , organic chemistry , combinatorial chemistry , medicinal chemistry , nuclear chemistry , enzyme , paleontology , biology
Abstract A practical protocol for the preparation of quinoxaline‐2,3(1 H ,4 H )‐diones through direct C( sp 2 )−H hydroxylation of quinoxalin‐2(1 H )‐ones in recyclable DL‐α‐Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) (TPGS‐750‐M/H 2 O) was developed. The target products were exclusively generated and could be collected through extraction and recrystallization.